1. Exploration: Isolation and identification of bioactive natural products from rain forest plants , isolation and extraction of new bioactive natural products from tropical forest plants, etc.
“Pharmaceuticals” were born from organic compounds produced by nature, that is, natural products.
Even today, about half of the medicines actually used are natural products or compounds derived from natural products. It is said that there are many natural products on the road that are candidates for medicines, especially in tropical forest plants that are in danger of disappearing. In our laboratory, we focus on tropical forest plants and conduct research to find new bioactive natural products. The future “drug seeds” found by the exploration team will be guided to “drug candidates” by the drug discovery team. This research is mainly conducted in collaboration with the National Cancer Institute (NIH).
2. Drug discovery: Development of drug seeds based on natural products ~ Design, synthesis, structure activity relationship and mechanism of discovery
and development of drug seeds based on natural products
~ Design, synthesis, structure activity relationship and mechanism of action study ~
3. Quality evaluation of herbal medicines by DNA analysis, chemincal constituents and activity
[Quality of crude drugs] Among naturally derived medicines, those that are either as they are or that have undergone simple processing are called “herbal medicines”. Crude drugs have many factors that change their quality, such as the place of origin and the growing environment. Its control is very important because quality has a direct impact on drug efficacy.