Modern drug discovery and today’s pharmacopeia is largely benefited from nature. More than 50% of approved drugs are natural products or natural product derivatives. It is estimated that there are about a million natural products have been isolated and many of them have been subjected to experimental assays to evaluate quantitative biological activities. However, there is a lack of an integrated datahouse to assemble these valuable data from individual literatures and provide to research community. With the motivation of addressing this gap, the Natural Product Activity and Species Source Database (NPASS) is developed to provide a freely accessible database integrating detailed information of species sources and biological activities of natural products.