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May 2011

Month: May 2011

Dictionary of Alkaloids, 2nd Edition

By: John Buckingham, Keith H. Baggaley, Andrew D. Roberts, Laszlo F. Szabo

Book Description:

While some of the most commonly investigated — and most notorious — chemicals in the world are alkaloids, many modern medicines are also based on alkaloid structures. Chemists continue to explore new synthetic routes and alkaloid derivatives in search of drug candidates for fighting disease.

Drawn from the venerable Dictionary of Natural Products, the second edition of the Dictionary of Alkaloids categorizes all known alkaloids, presenting concise chemical, structural, and physical data. The addition of an authoritative foreword, written by Geoffrey Cordell, eminent alkaloid chemist and Editor-in-Chief of the prestigious series The Alkaloids, Chemistry and Biology, sets the scene for this fascinating subject.

(more…)

May 28, 2011 / by Najib

The Alkaloids Chemistry and Pharmacology, Volume 04

By : R.H.F Manske, H.L. Holmes

Once I had this book borrowed from a local library. It is an extensive alphabetical list of alkaloids containing a brief chemical, physical and pharmaceutical info under each alkaloid name. (Eg. melting points of the substance and its salts, solubilities, crystallisation, angles of rotation of polarised light, effects on ingestion, occurence in nature, etc.). Anyone with an interest in plant substances will find it interesting. The copy I have seen was printed in 1947 in New York, so today it may be a little out of date.

  • Publisher: Academic Press Inc
  • Number Of Pages: 357
  • Publication Date: 1954-12
  • ISBN-10 / ASIN: 0124695043
  • ISBN-13 / EAN: 9780124695047

May 28, 2011 / by Najib

Alkaloids: Chemical and Biological Perspectives, Volume 14

By : S.W. Pelletier

Book Description:

Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinoline alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinoline alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the various classes of these alkaloids. The alkaloids are also categorized by their molecular weights and structural types.

(more…)

May 28, 2011 / by Najib

Recent Advances in Polyphenol Research (Volume 1)

By: Fouad Daayf, Vincenzo Lattanzio

Book Description:

Polyphenols are the second most abundant class of substances in nature, and include tannins and flavonoids, many of which have extremely important antioxidant properties which have now been shown to have a key role in the prevention of cancer in humans.

This important book covers polyphenol chemistry, biosynthesis and genetic manipulation, ecology and plant physiology, food and nutritional aspects and the effects of polyphenols on health. Included within the contents are cutting edge chapters on biotic and abiotic stress in plants, safety and toxicity in foods, functionality and nutraceutical benefits in nutrition, and aspects of pharmaceutical and cosmetic discovery and development.

Sponsored by Groupe Polyphenols, this landmark book has been edited by Professor Fouad Daayf and Professor Vincenzo Lattanzio, who have drawn together an impressive list of internationally respected contributing authors, each providing a comprehensive review of the current situation regarding each important subject covered.
(more…)

May 28, 2011 / by Najib

Oxidants in Biology: a question of balance

By : Giuseppe Valacchi, Paul Davis

Book Description

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules ( DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing.

(more…)

May 28, 2011 / by Najib

Free Radical Damage and its Control, Volume 28 (New Comprehensive Biochemistry)

By : C.A. Rice-Evans, R.H. Burdon

Book Description:

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth.

(more…)

May 28, 2011 / by Najib

Plants: Diet and Health (British Nutrition Foundation)

By BNF (British Nutrition Foundation)

Book Description:

Report of the British Nutrition Foundation’s Task Force
Chairman of the Task Force: Professor Malcolm Jackson, University of Liverpool

Plants: Diet and Health is an extremely timely publication comprising the comprehensive and authoritative independent report of the British Nutrition Foundation’s Task Force concentrating on bioactive substances and antioxidant nutrients in plant foods. The book focuses on the present state of knowledge and the effect on good health through the intake of these substances in an appropriate diet, looking in detail at any possible protection afforded the body by these substances – against chronic disorders, particularly cancer and cardiovascular disease.

This landmark publication includes chapters covering the classification, mechanisms of action and bioavailability of bioactive substances in plants, as well as in-depth coverage of the major plant foods: fruit, vegetables, cereals, nuts and pulses. Important chapters also cover the influence of the gut microflora, the effect of agronomy, storage, preservation, processing and cooking on bioactive substances, and the public health nutrition implications of all the issues raised.
(more…)

May 28, 2011 / by Najib

Oxidative Stress and Antioxidant Protocols (Methods in Molecular Biology Vol 186)

By : Donald Armstrong

Book Description:

Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.

  • Publisher: Humana Press
  • Number Of Pages: 336
  • Publication Date: 2002-02-15
  • Sales Rank: 1695348
  • ISBN / ASIN: 0896038505
  • EAN: 9780896038509
  • Binding: Hardcover
  • Manufacturer: Humana Press
  • Studio: Humana Press
May 28, 2011 / by Najib

Biomarkers for Antioxidant Defense and Oxidative Damage

By : Giancarlo Aldini, Kyung-Jin Yeum, Etsuo Niki, Robert M. Russell

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases.

Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.

(more…)

May 28, 2011 / by Najib

Free Radicals and Antioxidant Protocols, 2nd Edition (Methods in Molecular Biology, Vol. 610)

By : Rao M. Uppu, Subramanyam N. Murthy, William A. Pryor, Narasimham L. Parinandi

In recent years there has been a growing demand to achieve more rapid and accurate detection of RONs (reactive oxygen and nitrogen species), which affect normal physiological processes and pathological conditions, and also of redox stress. In Free Radicals and Antioxidant Protocols, Second Edition, world-renowned researchers respond to this need, considering the most recent analytical and technological aspects of the detection and determination of RONs, and of oxidative, nitrative, nitrosative, and redox stress in biological systems in vivo and in vitro. Chapters include protocols to establish biomarkers for the oxidative stress-induced genetic damage in cellular and animal models, provide novel methods and technologies for analyzing peroxidized lipids, describe techniques for gene therapy, and present methods of EPR imaging of free radicals and oxygen in vivo. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and user-friendly, Free Radicals and Antioxidant Protocols, Second Edition, is an essential guide for the novice and expert researcher alike.

May 28, 2011 / by Najib

Understanding the Antioxidant Controversy: Scrutinizing the Fountain of Youth (The Praeger Series on Contemporary Health and Living)

By : Paul E. Milbury, Alice C. Richer

Current scientific evidence suggests that free radicals— unstable by-products produced by normal human metabolic processes—damage the body, resulting in chronic health disorders and degenerative changes associated with aging. Nutritional products on the market today promise antioxidants can reduce—possibly even reverse—damage caused by these free radicals. If true, that would mean less chronic disease and premature aging, at the very least. But are antioxidants indeed the new Fountain of Youth? Media reports extol antioxidants as the solution to disease and aging, and some studies do seem to back up those reports. Yet the studies that have been completed are far from conclusive, and taking antioxidant supplements can be dangerous. This book explores current thinking, analyzes studies, and answers the questions: What are antioxidants? What do they do? Is there any real benefit to taking them as supplements? Are there real dangers for me?Media report preliminary and conflicting scientific studies on antioxidants, notwithstanding the fact that the final analysis about their effectiveness and safety is incomplete. The result is increasing sales of dietary supplements and so-called functional foods or nutraceuticals that are not regulated, nor proven, and a possible public safety crisis from hypersupplementation. Milbury and Richer bring us up to date, sharing nuances and emerging news regarding antioxidants—and their dangers. Understanding the Antioxidant Controversy is an educated consumers’ and health professionals’ guide to this controversial topic.

May 28, 2011 / by Najib

Spices: Flavor Chemistry and Antioxidant Properties (Acs Symposium Series)

By : Sara J. Risch, Chi-Tang Ho

Provides a general overview of spice chemistry. Discusses the characterization, extraction, and intensity of flavors. Identifies the flavor components and antioxidant properties of specific spices. Includes methods for identifying specific spices in blends and proving authenticity of spices. Discusses the antioxidant properties of spices with emphasis on potential health benefits of these spices.

May 28, 2011 / by Najib

The antioxidant vitamins C and E

By : Lester Packer

The proceedings of a March 2002 symposium at the World Congress of the Oxygen Club, in Santa Barbara, California present 19 papers reporting recent findings about the body’s two major dietary antioxidants. Introductory papers on each trace the history of research on them. Other topics include vitamin C pharmacokinetics in healthy men and women, potential adverse effects, the ongoing controversy about the bioavailability and biopotency of vitamin E in humans, and prospects for disease prevention and therapy. Annotation (c)2003 Book News, Inc., Portland, OR

May 28, 2011 / by Najib

Department of Medicinal Chemistry and Pharmacognosy, UIC

Welcome to the Department of Medicinal Chemistry and Pharmacognosy

The Department of Medicinal Chemistry and Pharmacognosy is located in the College of Pharmacy, and is an integral part of the University of Illinois at Chicago Health Science Center. The two graduate programs that constitute the core teaching mission of the department are Medicinal Chemistry and Pharmacognosy. The Medicinal Chemistry program includes research in traditional synthetic medicinal chemistry but also incorporates cancer biology and neuroscience research. Pharmacognosy is the study of the chemistry, biochemistry, biology, taxonomy, and ethnobiology of natural products from plant, marine and other life origins. The overarching aim of research programs in the two complementary areas is translational drug discovery. The scopes of both fields are sufficiently broad to give students with many different science backgrounds a rewarding and challenging program of study. Areas of active interest include natural products chemistry, organic synthesis of medicinal agents, computational chemistry, structural biology, cell and molecular biology, drug metabolism, bioanalytical and molecular toxicology, and animal models. Our current research foci are cancer, women’s health, neurodegenerative and related psychiatric disorders, and anti-infectives.

(more…)

May 9, 2011 / by Najib

Department of Pharmacognosy, University of Mississippi

Department Chair

Welcome to the Department of Pharmacognosy at the University of Mississippi. Pharmacognosy as a constituent scientific discipline has for nearly 200 years referred to studies of “natural product drugs”. During the second half of the 20th century, Pharmacognosy evolved from being a descriptive botanical subject to one exhibiting a more chemical and biological focus. The advent of the 21st century has given new relevance to Pharmacognosy teaching in academic pharmacy institutions, as a result of the explosive growth in both the use of herbal remedies (phytomedicines) and the discovery of bioactive products from marine resources. Pharmacognosy research areas are continually expanding, and currently include aspect of cell and molecular biology in relation to natural products, ethnobotany and phytotherapy, in addition to the more traditional analytical method development and phytochemistry.
(more…)

May 9, 2011 / by Najib

Pharmacognosy.com

ABOUT OUR CONSULTING SERVICES
Receive support from an independent source, qualified by training and experience
Dr. Marilyn Barrett has a multi-disciplinary background with broad range of experience in medicinal plant research including taxonomic botany, phytochemistry and pharmacology. She has 25 years experience in this field and has been an independent consultant since 1994.

In depth profiling on your product or product idea

Use the information you receive from us to make educated decisions.
(more…)

May 9, 2011 / by Najib

The School of Pharmacy, University of London

The School of Pharmacy, University of London is the only free-standing specialist school in the UK dedicated entirely to teaching and research in pharmacy and pharmaceutical sciences; with world-class teaching and a top rated research quality profile. Its mission is to lead in education, research and policy development that benefits patients and healthcare practice, medicines discovery and development, and society; focusing on four key areas – Drug Discovery, Formulation Sciences, Neuroscience, and Medicines Use and Health; and help develop new areas of significance, such as Behavioural Medicine, Paediatric Pharmacy, Gene Therapy and Nanomedicine.
(more…)

May 9, 2011 / by Najib

Traditional Medicine: A Global Perspective

By Steven B., Ph.D. Kayne

Book Description:

This is a contributed text on traditional medicines throughout the world. Almost 20 years ago the World Health Organization estimated that ‘In many countries, 80 per cent or more of the population living in rural areas are cared for by traditional practitioners and birth attendants’. It has since revised its view, adopting a rather safer position, now stating: ‘most of the population of most developing countries regularly use traditional medicine’. Whereas most people use traditional medicine in developing countries, only a minority have regular access to reliable modern medical services. Countries in Africa, Asia and Latin America use traditional medicine (TM) to help meet some of their primary health care needs. In Africa, up to 80 per cent of the population uses traditional medicine for primary health care. In industrialized countries, adaptations of traditional medicine are termed ‘Complementary’ or ‘Alternative’ (CAM). Over one-third of the population in developing countries lack access to essential medicines. The provision of safe and effective traditional medicine therapies could become a critical tool to increase access to health care.

  • Publisher: Pharmaceutical Press
  • Number Of Pages: 331
  • Publication Date: 2009-12-02
  • ISBN-10 / ASIN: 0853698333
  • ISBN-13 / EAN: 9780853698333
May 9, 2011 / by Najib

The Wildflower Center

Lady Bird Johnson, our former first lady, and actress Helen Hayes founded an organization in 1982 to protect and preserve North America’s native plants and natural landscapes. First as the National Wildflower Research Center and later as the Lady Bird Johnson Wildflower Center, this special place exists to introduce people to the beauty and diversity of wildflowers and other native plants. Every day, the Wildflower Center brings life to Mrs. Johnson’s vision in its public gardens, its woodlands and sweeping meadows as well as in internationally influential research. In 2006, the Center became an Organized Research Unit of the University of Texas at Austin.

URL : http://www.wildflower.org

May 9, 2011 / by Najib
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