Phenolic Compound Biochemistry

By : Wilfred Vermerris, Ralph Nicholson

  • Publisher: Springer
  • Number Of Pages: 276
  • Publication Date: 2007-04-04
  • Sales Rank: 2096263
  • ISBN / ASIN: 1402051638
  • EAN: 9781402051630
  • Binding: Hardcover
  • Manufacturer: Springer
  • Studio: Springer

Book Description:

How does the consumption of red wine reduce heart disease? How does a plant battle an invading fungus using physical and chemical defense mechanisms? How are tannins used in leather production synthesized?

These are just a few examples that illustrate the chemical diversity and use of phenolic compounds, the topic of ‘Phenolic Compound Biochemistry’.

(more…)

Chemistry and Biology of Ellagitannins: An Underestimated Class of Bioactive Plant Polyphenois

by:  Stephane Quideau

Book Description :

This book is the first of its kind that focuses on the chemistry and biology of ellagitannins, a special class of naturally occurring polyphenols which have so far not received the attention they deserve. These polyphenolic substances are found in many plants, including numerous food sources. They not only exhibit unique structural features that fascinate most chemists who are aware of their existence, but also express remarkable biological activities that have yet to attract the interest of the pharmaceutical industry. This is surprising because ellagitannins have been identified as active principles in traditional Chinese medicines. The principal aim of this book is to set the record straight.

(more…)

Advances in Plant Glycosides, Chemistry and Biology (Studies in Plant Science, Volume 6)

by: Chong-Ren Yang, Osamu Tanaka

  • Publisher: Elsevier Science Pub Co
  • Number Of Pages: 458
  • Publication Date: 1999-02-01
  • Sales Rank: 5535681
  • ISBN / ASIN: 0444501800
  • EAN: 9780444501806
  • Binding: Hardcover
  • Manufacturer: Elsevier Science Pub Co
  • Studio: Elsevier Science Pub Co

Book Description:

In the plant kingdom a variety of chemical constituents occur in a glycoside form (conjugation with sugar). Glycosides are important, secondary metabolites. The structural diversity is a result of the vast amount of varieties and stereochemical configurations of the sugar component. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, other simple phenolics, and isothiocyanate. However, biological activities of glycosides are, in many cases, susceptible to the nature of sugar moieties, even though their aglycone is the same.

Since the 80s, plant glycosides have been attracting an increasing volume of interest from botanists and phytochemists world-wide for the following reasons:

• They are difficult to isolate and purify

• They have a very important biological function in plant life and remarkable biological activities

• They are a very important resource of natural medicine, health food, cosmetics and food

Synthesis and Characterization of Glycosides

By : Marco Brito-Arias

  • Publisher: Springer
  • Number Of Pages: 352
  • Publication Date: 2006-12-12
  • Sales Rank: 2575409
  • ISBN / ASIN: 0387262512
  • EAN: 9780387262512
  • Binding: Hardcover
  • Manufacturer: Springer

Book Description:

This textbook discusses glycosides, which is an important area of sugar chemistry. Arias describes the general procedures commonly used for preparing a wide range of O-N- and C-glycosides, focusing on the preparation of the main glycosyl donors, and the coupling reaction conditions needed for the glycoside bond formation. Since characterization is also a very important topic to be treated, there is an introductory analysis about NMR spectroscopy, X-Ray diffraction and mass spectra of glycosides.

(more…)

Peyote and Other Psychoactive Cacti

By Adam Gottlieb

  • Publisher: Ronin Publishing
  • Number Of Pages: 96
  • Publication Date: 1997-07-07
  • ISBN-10 / ASIN: 091417195X
  • ISBN-13 / EAN: 9780914171959
  • Binding: Paperback

Book Description:

Classic on peyote an psychoactive cacti growing. Describes obtaining seeds, growing, cloning and grafting, and extracting maximum output of mescaline and other alkaloids. Includes Peyote, San Pedro, Donana and other cacti. Discusses legal aspects with appendix from attorney Richard Glen Boire. List of Suppliers.

Chromatography of Alkaloids

By R. Verpoorte, A.Baerheim Svendsen

  • Publisher: Elsevier Science Ltd
  • Number Of Pages: 466
  • Publication Date: 1984-09
  • ISBN-10 / ASIN: 044442265X
  • ISBN-13 / EAN: 9780444422651

Book Description:

The first of two books which provide an unparalleled reference source and handbook for everyone involved with alkaloid analyses. The first volume gives a comprehensive summary of the literature on thin layer chromatography of alkaloids. It presents the most effective methods for the separation and detection of alkaloids occurring in plant material, biological material, pharmaceutical preparations and drugs of abuse.

Alkaloids – Secrets of Life:: Alkaloid Chemistry, Biological Significance, Applications and Ecological Role (Alkaloids: Chemical and Biological Perspectives)

by: Tadeusz Aniszewski

Alkaloids, represent a group of interesting and complex chemical compounds, produced by the secondary metabolism of living organisms in different biotopes. They are relatively common chemicals in all kingdoms of living organisms in all environments. Two hundred years of scientific research has still not fully explained the connections between alkaloids and life.Alkaloids-Chemistry, Biological Significance, Applications and Ecological Role provides knowledge on structural typology, biosynthesis and metabolism in relation to recent research work on alkaloids. Considering an organic chemistry approach to alkaloids using biological and ecological explanation.

Within the book several questions that persist in this field of research are approached as are some unresearched areas. The book provides beneficial text for an academic and professional audience and serves as a source of knowledge for anyone who is interested in the fascinating subject of alkaloids. Each chapter features an abstract. Appendices are included, as are a listing of alkaloids, plants containing alkaloids and some basic protocols of alkaloid analysis. * Presents the ecological role of alkaloids in nature and ecosystems * Interdisciplinary and reader friendly approach* Up-to-date knowledge

(more…)

Plant Alkaloids: A Guide to Their Discovery and Distribution

By Robert F Raffauf, Lyle E Craker

Book Description:

Plant Alkaloids: A Guide to Their Discovery and Distribution serves as a record of both the positive and negative results obtained in the screening of more than 20,000 plant species for alkaloids in a forty-year search for new medicinal agents and other pharmacological substances. Designed to increase general knowledge of the Plant Kingdom, this book equips present and future generations of phytochemists with the skills and knowledge necessary for developing new alkaloid compounds. Recording the results of screening tests from approximately 400 genera of plants found primarily in zones beneath 45? N Latitude, Plant Alkaloids contributes to the efforts to calculate and safeguard the resources of the rainforests of the world. By offering results `from the field,’Plant Alkaloids surpasses the tradition of books on alkaloid chemistry that only emphasize the chemical and physical properties of known compounds, their established structures, biogenetic origins, taxonomic usefulness, and pharmacological actions. These results, in many cases, constitute the first record of the probable presence of alkaloids in the species under study. By documenting both positive and negative results, Plant Alkaloids directs the search for potentially new and useful compounds, while alleviating much of the time and expense of screening plants where results have already been obtained.An invaluable reference book for scientists in any of the life sciences, Plant Alkaloids provides a general index containing references to standard works on alkaloid chemistry and the subject?s vast literature. In addition to offering a description of the size of each plant family and its economic importance, this book also lists the genera and species of each plant tested according to accepted taxonomic names and notes disagreement over taxonomic assignment where it exists.

(more…)

Cinchona Alkaloids in Synthesis and Catalysis: Ligands, Immobilization and Organocatalysis

By Choong Eui Song

Book Description

This comprehensive review of cinchona–based chiralilty inducers and their applications covers every topic, including ligands, immobilization and organocatalysis. Each chapter summarizes the scope and limitations of the new methods and technologies, while the final chapter contains carefully selected working procedures of cinchona alkaloid–promoted reactions organized according to reaction type.
Invaluable reading for anyone wanting to learn about the current state of this hot topic.

From the Back Cover This first comprehensive review of cinchona–based chiralilty transmitters and their applications covers all relevant topics, including ligands, organocatalysis and modern analytics. With contributions from academia and industry, each chapter summarizes the scope and limitations of the new methods and technologies, while the final chapter contains carefully selected representative Cinchona–promoted catalytic examples, organized by reaction types.

(more…)

Dictionary of Alkaloids, 2nd Edition

By: John Buckingham, Keith H. Baggaley, Andrew D. Roberts, Laszlo F. Szabo

Book Description:

While some of the most commonly investigated — and most notorious — chemicals in the world are alkaloids, many modern medicines are also based on alkaloid structures. Chemists continue to explore new synthetic routes and alkaloid derivatives in search of drug candidates for fighting disease.

Drawn from the venerable Dictionary of Natural Products, the second edition of the Dictionary of Alkaloids categorizes all known alkaloids, presenting concise chemical, structural, and physical data. The addition of an authoritative foreword, written by Geoffrey Cordell, eminent alkaloid chemist and Editor-in-Chief of the prestigious series The Alkaloids, Chemistry and Biology, sets the scene for this fascinating subject.

(more…)

The Alkaloids Chemistry and Pharmacology, Volume 04

By : R.H.F Manske, H.L. Holmes

Once I had this book borrowed from a local library. It is an extensive alphabetical list of alkaloids containing a brief chemical, physical and pharmaceutical info under each alkaloid name. (Eg. melting points of the substance and its salts, solubilities, crystallisation, angles of rotation of polarised light, effects on ingestion, occurence in nature, etc.). Anyone with an interest in plant substances will find it interesting. The copy I have seen was printed in 1947 in New York, so today it may be a little out of date.

  • Publisher: Academic Press Inc
  • Number Of Pages: 357
  • Publication Date: 1954-12
  • ISBN-10 / ASIN: 0124695043
  • ISBN-13 / EAN: 9780124695047

Alkaloids: Chemical and Biological Perspectives, Volume 14

By : S.W. Pelletier

Book Description:

Volume 14 of this series presents three interesting reviews of research on alkaloids. Chapter 1, by Paul L. Schiff, Jr., is a monumental effort, presenting a selective, comprehensive tabular review of research on the bisbenzylisoquinoline alkaloids, with an analysis of the respective alkaloid types. The chapter should serve as a very useful tool for the bench research scientist who is involved in the isolation and elucidation of structures of bisbenzylisoquinoline alkaloids. Moreover, the data in these tables provides the botanical distribution and occurrence (family, genus, species) of the various classes of these alkaloids. The alkaloids are also categorized by their molecular weights and structural types.

(more…)

Recent Advances in Polyphenol Research (Volume 1)

By: Fouad Daayf, Vincenzo Lattanzio

Book Description:

Polyphenols are the second most abundant class of substances in nature, and include tannins and flavonoids, many of which have extremely important antioxidant properties which have now been shown to have a key role in the prevention of cancer in humans.

This important book covers polyphenol chemistry, biosynthesis and genetic manipulation, ecology and plant physiology, food and nutritional aspects and the effects of polyphenols on health. Included within the contents are cutting edge chapters on biotic and abiotic stress in plants, safety and toxicity in foods, functionality and nutraceutical benefits in nutrition, and aspects of pharmaceutical and cosmetic discovery and development.

Sponsored by Groupe Polyphenols, this landmark book has been edited by Professor Fouad Daayf and Professor Vincenzo Lattanzio, who have drawn together an impressive list of internationally respected contributing authors, each providing a comprehensive review of the current situation regarding each important subject covered.
(more…)

Oxidants in Biology: a question of balance

By : Giuseppe Valacchi, Paul Davis

Book Description

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules ( DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing.

(more…)

Free Radical Damage and its Control, Volume 28 (New Comprehensive Biochemistry)

By : C.A. Rice-Evans, R.H. Burdon

Book Description:

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth.

(more…)

Plants: Diet and Health (British Nutrition Foundation)

By BNF (British Nutrition Foundation)

Book Description:

Report of the British Nutrition Foundation’s Task Force
Chairman of the Task Force: Professor Malcolm Jackson, University of Liverpool

Plants: Diet and Health is an extremely timely publication comprising the comprehensive and authoritative independent report of the British Nutrition Foundation’s Task Force concentrating on bioactive substances and antioxidant nutrients in plant foods. The book focuses on the present state of knowledge and the effect on good health through the intake of these substances in an appropriate diet, looking in detail at any possible protection afforded the body by these substances – against chronic disorders, particularly cancer and cardiovascular disease.

This landmark publication includes chapters covering the classification, mechanisms of action and bioavailability of bioactive substances in plants, as well as in-depth coverage of the major plant foods: fruit, vegetables, cereals, nuts and pulses. Important chapters also cover the influence of the gut microflora, the effect of agronomy, storage, preservation, processing and cooking on bioactive substances, and the public health nutrition implications of all the issues raised.
(more…)

Oxidative Stress and Antioxidant Protocols (Methods in Molecular Biology Vol 186)

By : Donald Armstrong

Book Description:

Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.

  • Publisher: Humana Press
  • Number Of Pages: 336
  • Publication Date: 2002-02-15
  • Sales Rank: 1695348
  • ISBN / ASIN: 0896038505
  • EAN: 9780896038509
  • Binding: Hardcover
  • Manufacturer: Humana Press
  • Studio: Humana Press

Biomarkers for Antioxidant Defense and Oxidative Damage

By : Giancarlo Aldini, Kyung-Jin Yeum, Etsuo Niki, Robert M. Russell

Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases.

Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.

(more…)

Free Radicals and Antioxidant Protocols, 2nd Edition (Methods in Molecular Biology, Vol. 610)

By : Rao M. Uppu, Subramanyam N. Murthy, William A. Pryor, Narasimham L. Parinandi

In recent years there has been a growing demand to achieve more rapid and accurate detection of RONs (reactive oxygen and nitrogen species), which affect normal physiological processes and pathological conditions, and also of redox stress. In Free Radicals and Antioxidant Protocols, Second Edition, world-renowned researchers respond to this need, considering the most recent analytical and technological aspects of the detection and determination of RONs, and of oxidative, nitrative, nitrosative, and redox stress in biological systems in vivo and in vitro. Chapters include protocols to establish biomarkers for the oxidative stress-induced genetic damage in cellular and animal models, provide novel methods and technologies for analyzing peroxidized lipids, describe techniques for gene therapy, and present methods of EPR imaging of free radicals and oxygen in vivo. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and user-friendly, Free Radicals and Antioxidant Protocols, Second Edition, is an essential guide for the novice and expert researcher alike.

Understanding the Antioxidant Controversy: Scrutinizing the Fountain of Youth (The Praeger Series on Contemporary Health and Living)

By : Paul E. Milbury, Alice C. Richer

Current scientific evidence suggests that free radicals— unstable by-products produced by normal human metabolic processes—damage the body, resulting in chronic health disorders and degenerative changes associated with aging. Nutritional products on the market today promise antioxidants can reduce—possibly even reverse—damage caused by these free radicals. If true, that would mean less chronic disease and premature aging, at the very least. But are antioxidants indeed the new Fountain of Youth? Media reports extol antioxidants as the solution to disease and aging, and some studies do seem to back up those reports. Yet the studies that have been completed are far from conclusive, and taking antioxidant supplements can be dangerous. This book explores current thinking, analyzes studies, and answers the questions: What are antioxidants? What do they do? Is there any real benefit to taking them as supplements? Are there real dangers for me?Media report preliminary and conflicting scientific studies on antioxidants, notwithstanding the fact that the final analysis about their effectiveness and safety is incomplete. The result is increasing sales of dietary supplements and so-called functional foods or nutraceuticals that are not regulated, nor proven, and a possible public safety crisis from hypersupplementation. Milbury and Richer bring us up to date, sharing nuances and emerging news regarding antioxidants—and their dangers. Understanding the Antioxidant Controversy is an educated consumers’ and health professionals’ guide to this controversial topic.

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