Premlata Singariya, Padma Kumar, Krishan K Mourya
Journal of Pharmaceutical Negative Results 2013 4(1):71-75
Aim: The aim of present study is to investigate the antibiotic activity of seeds of Cenchrus setigerus and Cenchrus ciliaris extracts, in order to use them as a possible source of new anti-microbial substances against important human pathogens. Materials and Methods: Crude extracts of seeds of both species of Cenchrus grass were evaluated against some important G-ve bacteria. Escherichia coli, Raoultella planticola, Enterobacter aerogenes and one fungus Aspergillus flavus. The dried and powdered seeds were successively extracted with hexane, toluene, isopropyl alcohol, acetone and ethanol using the soxhlet assembly. The antimicrobial activity assay was done by both disc diffusion and serial dilution methods. Results: The results indicate that all the extracts, in different polar solvents did not show any antibacterial activity against R. planticola or any antifungal activity against A. flavus. Conclusion: All extracts in the different polar solvents did not have or had very less antibacterial and antifungal activities.