Nilesh Gupta, UK Jain
Journal of Natural Pharmaceuticals 2010 1(1):2-13
Wound, a clinical entity, is as old as mankind and often possesses problems in clinical practice. Naturally, the investigative curiosity to promote healing continues since ages. A lot of research has been envisaged to develop better healing agents and it has been a challenging task to generate them and keep pace with the problems encountered. Several drugs of plant, mineral, and animal origin are described in the Ayurveda for their wound healing properties. Most of these drugs are derived from plants. Some of these plants have been screened scientifically for the evaluation of their wound healing activity in different pharmacological models. Some Ayurvedic medicinal plants, namely Argemone mexicana, Boerhaavia diffusa, Catharanthus roseas, Diospyros cardifolia, Eclipta alba, Ficus religiosa, Hypericum perforatum, Lawsonia inermis, Merremia tridentate, and Swertia chirata, were found to be effective in experimental models. The rapidity of wound healing depends, to a considerable extent, on the contraction that begins a few days after injury and continues for several weeks. In the present review, attempts are made to understand various aspects of wound healing in terms of percentage closure of wound, period of complete epithelialization, tensile strength, histopathology, and weight of granuloma in different wound models.