Modern Phytomedicine:Turning Medicinal Plants into Drugs

Medicinal preparations derived from natural sources, especially from plants, have been in widespread use since time immemorial. Ancient texts of India and China contain exhaustive depictions of the use of a variety of plant-derived medications. In fact, plants remain the main source of medicines for a large proportion of the world’s population, particularly in the developing world, despite the advent of the pharmaceutical chemistry during the early twentieth century, which brought with it the ability to synthesize an enormous variety of medicinal drug molecules and allowed the treatment of previously incurable and/or life-threatening diseases.

(more…)

Medicinal Natural Products A Biosynthetic Approach

This book has been written primarily for pharmacy undergraduates to provide a modern text to complement lecture courses dealing with pharmacognosy and the use of natural products in medicine. Nevertheless, it should be of value in most other courses where the study of natural products is included, although the examples chosen are predominantly those possessing pharmacological activity.

For centuries, drugs were entirely of natural origin and composed of herbs, animal products, and inorganic materials. Early remedies may have combined these ingredients with witchcraft, mysticism, astrology, or religion, but it is certain that those treatments that were effective were subsequently recorded and documented, leading to the early Herbals. (more…)

BIOASSAY TECHNIQUES FOR DRUG DEVELOPMENT

The so-called “green wave”, triggered by a growing ecological awareness, has resulted in an increased interest in herbal formulations throughout the world, particularly in the last decade. The consumption of medicinal plants has almost doubled in the West during that period. The efficacy of a number of herbal formulations has been tested by valid phytopharmaceutical techniques and the number of plant-based drugs or health foods has increased steadily to meet the growing demand. Over the years a new relationship between phytochemists and pharmacologists has accordingly developed which, in many cases, has proved to be very productive.

(more…)

Tyler’s Herbs of Choice The Therapeutic Use of Phytomedicinals

Since publication in 1999 of the first revision of Herbs of Choice, a plethora of publications has extended both the range and depth of herbal medicinal science. Notable has been the introduction to the West of a number of herbs long popular in Eastern traditional medicine systems. Prominent among these have been Andrographis paniculata, Petasites hybridus (butterbur), Centella asiatica (gotu kola), Bacopa monnieri, and Citrus aurantium (bitter orange) as an ephedra substitute.

There has also been an explosion of concern and scientific investigation into the potential for herb–drug interaction influencing clinical outcomes— from grapefruit (Citrus x paradisi) to St. John’s wort (Hypericum perforatum). Examination of bleeding and coagulation associated with herbs has been expanded. Recent research has also clarified certain aspects of the mechanisms of action of a number of popular herbs, such as feverfew, ginkgo, and ginseng. Particularly, a wholesale revision of the feverfew treatment has been effected. Phytochemical treatment of liver disease and the activity of phytoestrogens have been more widely explored.

(more…)

Spectral Data Base (SDBS)

Introduction

SDBS is an integrated spectral database system for organic compounds,which includes 6 different types of spectra under a directory of the compounds. The six spectra are as follows, an electron impact Mass spectrum (EI-MS), a Fourier transform infrared spectrum (FT-IR), a 1H nuclear magnetic resonance (NMR) spectrum, a 13C NMR spectrum, a laser Raman spectrum, and an electron spin resonance (ESR) spectrum. We started the studies on the spectral database system in early 1970s. The construction of the database in the present format was started in 1982 in a mainframe computer that was finished at the end of March 1999. In 2001, National Metrology Institute of Japan (NMIJ) under National Institute of Advanced Industrial Science and technology (AIST) started to manage and to maintain the SDBS. Currently, EI-MS spectrum, 1H NMR spectrum, 13C NMR spectrum, FT-IR spectrum, and the compound dictionary are active for correcting and maintenance of the data. Since 1997, SDBS has opened to the public with free of charge through TACC (Tsukuba Advanced Computing Center) as RIO-DB (Research Information Data Base). The total accumulated number of access almost reached 200 million at the end of February, 2008. SDBS is a fact database that contains spectral pattern and has been an important database that sends information from Japan to all over the world. The numbers of the data present at the end of March, 2010 were as follows.

URL : http://riodb.ibase.aist.go.jp/riohomee.html

(more…)

Biological Magnetic Resonance Data Bank (BMRBS)

BMRB’s mission is to collect, archive, and disseminate (worldwide in the public domain) the important quantitative data derived from NMR spectroscopic investigations of biological macromolecules. Relevant data are deposited by the scientists who generate them, and in consultation with these scientists, BMRB resolves any problems with the self-consistency and completeness of the deposition. In collaboration with the Protein Data Bank, BMRB provides links between the spectral data and associated atomic coordinates. BMRB works with the user community to develop formats for these data that can be parsed by computers and used for knowledge generation, alone and in conjunction with information from other databases. BMRB’s goal is to empower scientists in their analysis of the structure, dynamics, and chemistry of biological systems and to support further development of the field of biomolecular NMR spectroscopy. Through international collaborations and mirror sites, BMRB endeavors to involve the participation of a wider group of scientists and to enhance its services worldwide.

URL : http://www.bmrb.wisc.edu/

International Journal of Pharmacognosy and Phytochemical Research

Introduction

International Journal of Pharmacognosy and Phytochemical Research (IJPPR) is a quarterly published online journal. It is to serve the interests of the research-oriented and professional section in the fields of pharmaceutical sciences. The current emphasis of the journal includes (but is not limited to) the following areas: Pharmacogenomics, Pharmaceutical Biotechnology, Pharmaceutical biosciences, Pharmacognosy, Phytochemistry by publishing original research work and review articles. The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication by the Journal.

Ethical issues

The Publishing House is committed to the timely publication of peer-reviewed articles in journals and encyclopedias. The Publishing House requires all authors to comply fully with current ethical standards for publication in their disciplines. Manuscripts submitted to the journal must represent reports of original research, and the original data must be available for review by the editor if necessary. All authors of a manuscript must have agreed to its submission and are responsible for its content, including appropriate citations and acknowledgments, and must also have agreed that the corresponding author has the authority to act on their behalf in all matters pertaining to publication of the manuscript. By submission of a manuscript to the journal, the authors guarantee that they have the authority to publish the work and that the manuscript, or one with substantially the same content, was not published previously, and is not being considered for publication elsewhere. When submitting papers for publication, it is expected that the authors will provide written assurance and describe the novelty of their work or in the approach taken in their research in a covering letter.

URL : http://www.ijppr.com/

Journal of Natural Products

History of Journal

The Journal of Natural Products has been the scientific journal of the American Society of Pharmacognosy (http://www.phcog.org) since 1961, but was first published as Lloydia in 1938 by the Lloyd Library and Museum, 917 Plum Street, Cincinnati, Ohio 45202. This institution was founded by John Uri Lzloyd, and its development was also fostered by his brothers Curtis Gates Lloyd and Nelson Ashley Lloyd. The library is a repository of an internationally famous collection of literature in the natural sciences with preeminence in the pharmaceutical sciences, eclectic medicine, botany, and chemistry, and is available to scientists and others for reference and research. The Journal of Natural Products became known under its present title in 1978, during the editorial tenure of Professor Jack L. Beal of the College of Pharmacy, The Ohio State University. Originally a quarterly publication, it became a bimonthly journal in 1975, and has appeared monthly since 1992. The American Society of Pharmacognosy began to co-publish the Journal of Natural Products with the American Chemical Society in 1996.

Scope of the Journal

The Journal of Natural Products invites and publishes papers that make substantial and scholarly  contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, they may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from higher plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.

Impact Factor

The impact factor for the Journal of Natural Products has increased from 1.432 in 1997 to the highest ever level of 2.418 in 2006. Likewise, the total number of cites has increased from 3,364 in 1997 to 10,647 in 2006. The journal is ranked as #3 among medicinal chemistry journals in terms of its total number of cites, and is one of five American Chemical Society journals credited with nearly 40% of all citations in the field of Medicinal Chemistry.

URL : http://www.pharmacy.ohio-state.edu/programs/medchem/journal.cfm

Journal of Pharmacognosy and Phytotherapy (JPP)

About JPP

The Journal of Pharmacognosy and Phytotherapy (JPP) is an open access journal that provides rapid publication (monthly) of articles in all areas of the subject.

The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately one  month after acceptance. All articles published in the JPP will be peer-reviewed.

The Journal of Pharmacognosy and Phytotherapy will be published monthly (one volume per year) by Academic Journals.

Types of paper

Regular Articles: These should describe new and carefully confirmed findings, and experimental procedures should be given in sufficient detail for others to verify the work. The length of a full paper should be the minimum required to describe and interpret the work clearly.

Short Communications: A Short Communication is suitable for recording the results of complete small investigations or giving details of new models or hypotheses, innovative methods, techniques or apparatus. The style of main sections need not conform to that of full-length papers. Short communications are 2 to 4 printed pages (about 6 to 12 manuscript pages) in length.

Reviews: Submissions of reviews and perspectives covering topics of current interest are welcomed and encouraged. Reviews should be concise and no longer than 4 to 6 printed pages (about 12 to 18 manuscript pages). Review manuscripts are also peer-reviewed.

URL : http://www.academicjournals.org/jpp/Archive.htm

Search
Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Archives
MonTueWedThuFriSatSun
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
      1
2345678
9101112131415
16171819202122
23242526272829
30      
   1234
567891011
12131415161718
19202122232425
262728293031 
       
   1234
567891011
12131415161718
19202122232425
262728    
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
  12345
6789101112
13141516171819
20212223242526
27282930   
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
   1234
567891011
12131415161718
19202122232425
2627282930  
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
     12
3456789
10111213141516
17181920212223
24252627282930
       
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
  12345
6789101112
13141516171819
20212223242526
2728     
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
   1234
567891011
12131415161718
19202122232425
262728293031 
       
 123456
78910111213
14151617181920
21222324252627
282930    
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
   1234
567891011
12131415161718
19202122232425
2627282930  
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
  12345
6789101112
13141516171819
20212223242526
27282930   
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
1234567
891011121314
15161718192021
22232425262728
29      
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
      1
2345678
9101112131415
16171819202122
23242526272829
30      
   1234
567891011
12131415161718
19202122232425
262728293031 
       
 123456
78910111213
14151617181920
21222324252627
282930    
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
1234567
891011121314
15161718192021
22232425262728
2930     
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
  12345
6789101112
13141516171819
20212223242526
27282930   
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
      1
2345678
9101112131415
16171819202122
232425262728 
       
   1234
567891011
12131415161718
19202122232425
262728293031 
       
     12
3456789
10111213141516
17181920212223
24252627282930
       
      1
2345678
9101112131415
16171819202122
23242526272829
30      
   1234
567891011
12131415161718
19202122232425
262728293031 
       
 123456
78910111213
14151617181920
21222324252627
282930    
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
     12
3456789
10111213141516
17181920212223
2425262728  
       
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
      1
2345678
9101112131415
16171819202122
23242526272829
30      
   1234
567891011
12131415161718
19202122232425
262728293031 
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
1234567
891011121314
15161718192021
22232425262728
2930     
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
    123
45678910
11121314151617
18192021222324
25262728   
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
   1234
567891011
12131415161718
19202122232425
2627282930  
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
     12
3456789
10111213141516
17181920212223
24252627282930
       
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
      1
2345678
9101112131415
16171819202122
23242526272829
30      
   1234
567891011
12131415161718
19202122232425
262728293031 
       
  12345
6789101112
13141516171819
20212223242526
272829    
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
   1234
567891011
12131415161718
19202122232425
262728293031 
       
 123456
78910111213
14151617181920
21222324252627
282930    
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
   1234
567891011
12131415161718
19202122232425
2627282930  
       
1234567
891011121314
15161718192021
22232425262728
293031    
       
    123
45678910
11121314151617
18192021222324
25262728293031
       
  12345
6789101112
13141516171819
20212223242526
27282930   
       
      1
2345678
9101112131415
16171819202122
23242526272829
3031     
    123
45678910
11121314151617
18192021222324
252627282930 
       
 123456
78910111213
14151617181920
21222324252627
28293031   
       
 123456
78910111213
14151617181920
21222324252627
28      
       
     12
3456789
10111213141516
17181920212223
24252627282930
31      
  12345
6789101112
13141516171819
20212223242526
2728293031  
       
    123
45678910
11121314151617
18192021222324
25262728293031